We also recently reported that the simultaneous exposure of mice to certain pesticides ligands of the Constitutive Androstane Receptor (CAR) combined with an RXR ligand can induce the synergistic activation of this nuclear receptor, also eliciting combined effects on steatosis and hypercholesterolemia, mainly through increased free fatty acid uptake and increased cholesterol synthesis [23]. The gene discussed is NR1I3; the disease is familial hypercholesterolemia.