In 1993, mutations in the SOD1 gene were the first to be associated with familial ALS, and since that time over 185 ALS-linked SOD1 variants have been identified including D90A, A4V, H43R, L84V, G85R N86S, and G93A, and patients with different variants manifest varying features of onset and progression [7,8,9]. Here, SOD1 is linked to amyotrophic lateral sclerosis.