In this regard, it was observed that oncogenic chromatin remodeling and YAP-dependent transcription induced by the mTOR Complex 1 (mTORC1)– AT-rich interactive domain-containing protein 1A (ARID1A) axis promotes cancer cell growth and tumor development in different models for hepatocellular carcinoma (HCC). Here, ARID1A is linked to hepatocellular carcinoma.