CD27 is stimulated by interaction with CD70 (TNFSF7, CD27L) on mature DCs, activated B and T lymphocytes, and certain hematologic malignancies, and reduces FAS-L-mediated T-cell apoptosis (Figure 2) [130] by inducing BCL-XL and PIM-1 [131], thus limiting mitochondrial dysfunction [132]. The gene discussed is CD70; the disease is hematologic disorder.