Table 3 summarises the studies investigating the use of MSCs and MSC-derived exosomes in RA animal models. Interestingly, UC-MSCs were suggested to induce greater reductions in the levels of pro-inflammatory cytokines than MTX [123]. Moreover, the effects of UC-MSC treatment in CIA mice were similar to those of biological agents targeting TNF and CD20 [105]. This evidence concerns the gene TNF and rheumatoid arthritis.