CD8A and neoplasm: In the Py230-C57Bl/6J model (Figure 3C), passage 4 tumor-infiltrating CD8+T cells (at E:T ratio 20:1) from the HS cohort exerted significantly reduced cytotoxicity (23.8 ± 5.7%) compared to their passage 1 counterparts (71.4 ± 6.1%; p < 0.05).