In a similar manner, the CCL21a/ExoGM-CSF+Ce6 @nanoGel was created by combining CCL21a and ExoGM-CSF+Ce6 (tumor cell-derived exosomes with granulocyte–macrophage colony-stimulating factor (GM-CSF) mRNA encapsulated inside and sonosensitizer chlorin e6 (Ce6) incorporated in the surface). The gene discussed is CSF2; the disease is neoplasm.