It is important to note here that, because Akt plays a central role in metabolism and cell proliferation [12], the PI3K-Akt pathway drives tumorigenesis and/or tumor growth in some cancers [36,128] via mutations in Akt or upstream proteins (e.g., in EGFR or PI3K) that result in aberrant activation of the pathway. The gene discussed is EGFR; the disease is neoplasm.