BACH2 and acute promyelocytic leukemia: Previous studies identified that the small ubiquitin modifier (SUMO) sentrin-specific protease SENP3 serves as a sensor of metabolic status, particularly intracellular ROS, which regulates the nuclear translocation of SUMOylated BACH2 [80,81], the association of SUMOylated BACH2 with promyelocytic leukemia nuclear bodies, and the repression of associated transcriptional targets [65] (Figure 2 and Figure 4).