miR-373 has been previously shown to be elevated upon infection with HIV-1 [52], whereas miR-133 is known to play a role in vascular stress, remodeling, and cell survival [34] and previous study from our lab has also shown that lncRNA known to target miRNA-133 was elevated in HPASMC on the treatment of cocaine and HIV-Tat [85]. The gene discussed is TAT; the disease is infection.