For example, 6phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKBP3) involved in glycolysis is a target of six significantly altered miRNAs in EVs whereas Membrane Spanning 4-Domains A4A (MS4A4A) which belongs to tumor-associated macrophages is a target of four EV-linked miRNAs. This evidence concerns the gene MS4A4A and neoplasm.