Data from the literature demonstrate curcumin’s ability to modulate different signaling pathways involved in the development of neurodegenerative diseases, such as nuclear factor-erythroid 2-related factor 2 (Nrf2), serine/threonine kinase AKT, and transcription factor nuclear factor-kB (NF-kB) [11,12]. This evidence concerns the gene NFE2L2 and neurodegenerative disease.