In this observational and prospective study involving 167 chronic kidney disease (CKD) patients, it was observed that patients with the CG/GG genotype of vitamin K epoxide reductase complex subunit 1 (the target enzyme for warfarin) had a higher risk of coronary artery calcification (CAC) progression and poorer survival, suggesting the potential role of VK2. This evidence concerns the gene VKORC1 and chronic kidney disease.