Cardiac expression of OSTN is controversial (Schafer et al., 2018; Szaroszyk et al., 2022) but might be dependent on stress or overload, as evidenced by the impact of high‐intensity interval training (Jeremic et al., 2020) or preconditioning (Harris et al., 2023). Similar findings might underlie the regulation of OSTN in skeletal muscle (Kang et al., 2024; Subbotina et al., 2015) and in adipocytes in obesity (Choi et al., 2023; Nishizawa et al., 2004; Zhang et al., 2020). The gene discussed is OSTN; the disease is obesity due to melanocortin 4 receptor deficiency.