In this study, we demonstrated that miR‐874‐3p protect against IVDD by inhibiting NPC ferroptosis, apoptosis, ECM degradation and inflammatory response through the regulation of SLC7A11, GPX4, caspase3, MMP2, MMP3, TNF‐α, IL‐6 and IL‐1β expression in NPC. Here, MMP2 is linked to nasopharyngeal carcinoma.