Inflammatory vesicles trigger neutrophil pyroptosis, and neutrophils swell and undergo membrane lysis, releasing large amounts of immunomodulatory cytokines and chemokines, such as interleukin-10 (IL-10), interleukin-13 (IL-13), interleukin-8 (IL-8), macrophage inflammatory protein-1, MPO, histone G, and other granulomatous enzymes, which lead to increased lung load and, consequently, more severe inflammation and ALI [94–96]. Here, IL13 is linked to acute respiratory distress syndrome.