IL1RL2 and Chronic colitis: Chronic colitis and intestinal fibrosis are ameliorated when the IL36R gene is inhibited or knockout in mic, hinting that inhibition of IL-36R signal may be used as a clinical intervention in patients with IBD [178], which are further confirmed by the evidence of IL-36 isoforms, as well as the IL-36R/IL-1RAcP complex, being upregulated in IBD [179].