SYT11 and neoplasm: As shown in Fig. 4A, CpG-aggregated SYT11 methylation was significantly lower in tumor tissues than that in corresponding normal tissues for patients with BLCA (p ≤ 0.0001), BRCA (p ≤ 0.01), COAD (p ≤ 0.01), HNSC (p ≤ 0.0001), KIRC (p ≤ 0.0001), LIHC (p ≤ 0.001), LUAD (p ≤ 0.01), LUSC (p ≤ 0.0001), PCPG (p ≤ 0.05), PRAD (p ≤ 0.0001), READ (p ≤ 0.001), and UCEC (p ≤ 0.0001), while being the opposite for patients with CHOL (p ≤ 0.05).