The results showed that SYT11 promoter methylation was downregulated in patients with various tumors, including BLCA, BRCA, COAD, CESC, GBM, HNSC, KIRC, KIRP, LIHC, LUAD, LUSC, PRAD, READ, TGCT, and UCEC, but was lower in the primary tumor tissue then that in normal tissue only for the patients with CHOL. This evidence concerns the gene SYT11 and neoplasm.