Recently, the association between H. pylori infection and germline P variants in genes as BRCA1, BRCA2, ATM, and PALB2, has been described; people with H. pylori infection and germline mutations in those genes have a higher gastric cancer cumulative risk at 85 years of 45.5% (95% CI, 20.7 to 62.6); in contrast, the risk in people with H. pylori infection alone is 14.4% (95% CI, 12.2 to 16.6) [35]. This evidence concerns the gene BRCA1 and gastric cancer.