BRCA2 and breast cancer: Particularly, two BRCA2 families with a pathogenic variant were tested, one of the relatives had been diagnosed with BC at 41 years (c.1763_1766delATAA, p.Asn588Serfs*25; age diagnosis index case: 35 years), and another relative was diagnosed with breast and thyroid cancer at 64 years (c.3860delA, p.Asn1287Ilefs*6; age diagnosis index case: 42 years).