Some of those are related to AD, such as regulation of interferon-β production, regulation of inflammatory responses, upregulation of interleukin-6 production, cellular responses to lipopolysaccharide, microglial cell activation and synapse pruning, with average FCs of 0.95, 1.00, 1.22, 0.90, 1.21 and 2.33, respectively (Fig. 4B). This evidence concerns the gene IL6 and Alzheimer disease.