It has been reported that EZH2 depletion mediates histone H3K27 trimethylation and reduces the enrichment of DNMT1 on the miR-200b/a/429 promoter, thus abolishing transcriptional silencing of miRNAs and suppressing tumor growth in gastric cancer and glioblastoma [28]. This evidence concerns the gene DNMT1 and glioblastoma.