In intrahepatic cholangiocarcinoma (ICC), IL-6 increases the expression of circRNA GGNBP2 to encode the protein cGGNBP2-184aa, which in turn forms a positive feedback loop of IL-6/cGGNBP2-184aa/STAT3 to facilitate ICC progression [67]. This evidence concerns the gene IL6 and intrahepatic cholangiocarcinoma.