Pathophysiology of cancer-associated thrombosis stems from the hypercoagulable state related to the increasing production of substances like: tissue factor (TF), podoplanin (PDPN), neutrophil extracellular traps (NETs), and plasminogen activator inhibitor-1 (PAI-1) that has high procoagulant activity [8]. The gene discussed is F3; the disease is cancer.