In the present study, to increase the understanding of the genetic connection in between, we investigated the genetic variability of the SLC7A8/SLC3A2 genes, coding for the heteromeric transporter LAT2/4F2hc which mediates the cell-uptake of L-DOPA in kidney, in subjects stratified according to presence/absence of CKD and presence/absence of hypertension. Here, SLC3A2 is linked to chronic kidney disease.