An analysis of expression data from 467 GBM samples reveals that GBM patients with higher expression of autophagy genes have worse prognosis and damage-regulated autophagy modulator (DRAM1) gene upregulation is linked to the activation of mitogen-activated protein kinase (MAPK) in GSCs, playing a role in TMZ resistance [70]. Here, WNK2 is linked to glioblastoma.