Studies in many different tumors have shown that human regulatory B (Breg) cells secrete many cytokines (including IL-6, IL-10, IL-35, and TGF-β) to support the expansion of regulatory T cells (Tregs), tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs) around the tumor bed, driving these cells toward immune-suppressive phenotypes to enhance the tumor-promoting microenvironment [47]. This evidence concerns the gene TGFB1 and neoplasm.