TARDBP and Cognitive impairment: In bvFTD, plasma EV TDP-43 concentrations correlated with cognitive impairment, impaired functional activities, increased symptom severity, more severe psychiatric and behavior symptoms (MMSE, MoCA, FAQ, CDR-SB, CDR plus NACC FTLD, NPI-Q, CBI-M) (Fig. 3i,j (sEV), Supplementary Fig. 11k,l (mEV) and Supplementary Table 9).