TARDBP and amyotrophic lateral sclerosis: Plasma sEV TDP-43 distinguished ALS from HC, PSP and bvFTD with AUC values of 0.99, CI [0.97–1.00]; 0.99, CI [0.98–1.00]; and 0.91, CI [0.88–0.94] (Fig. 3b–d).