NEFL and amyotrophic lateral sclerosis: Plasma EV TDP-43 levels were highly correlated with plasma NfL concentrations in ALS and bvFTD (ALS sEV: r = 0.67, P < 0.0001; bvFTD sEV: r = 0.42, P < 0.0001; Extended Data Fig. 2c,d (sEV) and Supplementary Fig. 11g,h (mEV)).