MAPT and amyotrophic lateral sclerosis: Plasma EV 3R/4R tau ratios distinguished bvFTD from HC, ALS and PSP with high diagnostic accuracy (sEVs AUC 0.89–0.98 (Fig. 2d–f) and mEVs AUC 0.86–0.97 (Supplementary Fig. 7d,f); Supplementary Table 3).