After all, our grasp of genomic changes in PCK2 start and progression is rudimentary, and the molecular genetic modifications unique to HCC require further consideration summary, the aberrant expression of certain genes is crucial in the formation of hepatocellular carcinoma, which involves the determination of the most appropriate treatment and timing of various therapies at the level of molecular mechanism to obtain the best therapeutic effect. Here, PCK2 is linked to hepatocellular carcinoma.