To confirm the effects of androgen on endometrioid carcinoma progression in vivo, we conducted animal experiments using uterus-specific PTEN-deficient mice that spontaneously developed endometrial carcinoma of the uterus, and found that DHT decreased the proliferation of the spontaneously developed endometrioid carcinoma in ovariectomized Ptenff/PRcre/+ mice. This evidence concerns the gene PTEN and endometrioid adenocarcinoma.