Entirely new predictions include MAP3K21 (encoding a mixed-lineage kinase) in colorectal cancer, USP17L22 (encoding a deubiquitinating enzyme) in breast ductal carcinoma and TPTE (encoding a tyrosine phosphatase) in lung adenocarcinoma (Supplementary Table 5). The gene discussed is USP17L22; the disease is breast ductal adenocarcinoma.