Across drivers operating in several cancer types, the clearest examples of domain-specific driver mutations were in EGFR, where protein tyrosine and serine/threonine kinase domain mutations predominated in lung adenocarcinoma, in contrast to extracellular furin-like cysteine-rich region domain mutations in IDH wild-type glioblastoma (Supplementary Table 6 and Extended Data Fig. 4a). Here, MARK2 is linked to lung adenocarcinoma.