RB1 and neoplasm: In an expanded analysis of all LUAD datasets available through cBioPortal with available copy number and mutation data, we found that SHPRH was mutated or deeply deleted in ~4% (34/980) of tumors, similar in frequency to known LUAD tumor suppressor genes including RB1 (~6%), BRCA2 (~5%), BRCA1 (~3%) and PTEN (~2%) (Supplementary Fig. 2B).