SHPRH and neoplasm: Lastly, to determine whether evidence of increased DNA damage is associated with SHPRH inactivation in LUAD patients we separated tumors based on SHPRH inactivation status (mutation or deletion vs wildtype) and compared the degree of Tumor Mutational Burden (TMB), Mutational Count, and Fraction Genome Altered using sequence and clinical data from the LUAD TCGA PanCancer dataset [49].