Then, we revealed that inactivation of the mTOR signaling pathway by everolimus not only attenuated the cell migration, proliferation and angiogenesis mediated by depletion of RNF26 in ccRCC cells (Figs. 5f–h) but also abolished the ability of RNF26 to enhance tumor growth in vivo (Figs. 5i–k). The gene discussed is MTOR; the disease is nonpapillary renal cell carcinoma.