PAK4 and neoplasm: Despite patients with positive PAK4 expression in tumours showing a tendency toward a poorer prognosis, the Although the Kaplan–Meier survival analysis revealed no statistically significant association between PAK4 immunoreactivity in tumour cells and overall survival across all cases, patients with positive PAK4 expression in their tumours tended to have a poorer prognosis (P = 0.094, log-rank test, Supplementary Fig. S3).