IRF5 and hepatocellular carcinoma: In our pre-experiment, we found that ADRM1 was highly expressed in hepatocellular carcinoma and positively correlated with B cell biomarkers (CD19), CD8+T cell biomarkers (CD8A and CD8B), M1 macrophage biomarker (IRF5), M2 macrophage biomarker (VSIG4), Neutrophil biomarkers (CEACAM8 and ITGAM), and Dendritic cell biomarkers (HLA-DPB1, HLA-DRA, HLA-DPA1, and ITGAX) within the HCC context (Table1).