Pathway enrichment analysis showed that these common upregulated genes were mainly enriched in pathways such as cell cycle, retinoblastoma gene in cancer, extracellular matrix organization, PI3K-Akt signaling pathway and DNA damage response (Fig. 6C), while the common downregulated gene were mainly associated with cytokine signaling in immune system, TGF-beta signaling pathway, and cAMP signaling pathway (Fig. 6D). This evidence concerns the gene AKT1 and cancer.