The Pearson correlation analysis showed that MTMR3 and OSBPL2 had a strong positive correlation (GSE61144, correlation coefficient (CRC) = 0.93; GSE60993, CRC = 0.93), GAB2 and MTMR3 had a strong positive correlation (GSE61144, CRC = 0.96; GSE60993, CRC = 0.92), ALOX5 and CEBPD had a strong positive correlation (GSE61144, CRC = 0.94; GSE60993, CRC = 0.87), but ALOX5 and RARRES3 had a strong negative correlation (GSE61144, CRC = − 0.9; GSE60993, CRC = − 0.9). The gene discussed is OSBPL2; the disease is colorectal carcinoma.