In addition, evaluation of whether the K385A mutant had an effect on cation selectivity revealed an unaltered permeability ratio compared to WT TRPC3 (TRPC3: PCa/PCs = 1.13 ± 0.24 and K385A: PCa/PCs = 0.98 ± 0.16; Supplementary Fig. 6b). Here, TRPC3 is linked to posterior cortical atrophy.