CD19 and diffuse large B-cell lymphoma: Furthermore, in our coculture model established to examine the effects of M2 macrophages on CAR-T cell cytotoxicity against CD19-expressing DLBCL cells (DB cells) and the impact of CAR19 cells on M2 macrophages’ total cholesterol levels either within or secreted by M2 macrophages (Fig. 3e), M2 macrophages exhibited significantly lower cholesterol levels than control cells in the presence of CAR19 cells and a higher cholesterol level in the coculture medium.