To examine the effect of the TME of DLBCL cells on M2-polarized macrophages’ cytomembrane cholesterol levels, control cells, M2 and M2 ABCA1-knockdown (membrane cholesterol efflux transporters) macrophages (M2shABCA1) were cultured with conditioned medium from DLBCL (DB) cells (Fig. 3c). The gene discussed is ABCA1; the disease is diffuse large B-cell lymphoma.