Several missense mutations on p62 sequence have been identified in Paget’s disease of bone (PDB), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) [19], correlating with abnormalities in autophagy, NF-kB and Nrf2 signaling pathways [15]. Here, NFE2L2 is linked to frontotemporal dementia.