Early transformation of host immunity in lung tumorigenesis was verified to be strongly associated with the type of driver mutations.280 Mutant Kras induced stronger immune activation compared with that of EGFR mutations from normal and premalignant to cancerous states, including CD8+ T cell infiltration, a low ratio of CD4+/CD8+ T cells and Treg/CD8+ T cells, and higher T cell clonality.280 Indeed, the immunomodulatory roles of the two classic tumor driver mutations have been widely explored. This evidence concerns the gene CD8A and neoplasm.