On one hand, metabolites of tumor cells promote immunosuppressive effects,295,296 and in turn, phagocytosis of TAMs facilitates nutrient accumulation to meet energy requirement of tumor cells.297 On the other hand, there is nutritional competition between immune cells and tumor cells.298 mTORC1 signaling in TAMs plays a role in regulating the competition.299 Under normal protein diet conditions, the mTORC1 pathway is weakened in TAMs and thereby be enhanced in Myc-overexpressing tumor cells, resulting in a competitive advantage of tumor cells. This evidence concerns the gene MYC and neoplasm.