DOCK8 and B-cell chronic lymphocytic leukemia: Importantly, engagement of Siglec-6 with its ligand sTn resulted in increased DOCK8 recruitment at the cell membrane in MEC1-002 WT cells and B-CLL cells [2-fold, t(6) = 2.8, P = 0.03; and 2-fold, t(8) = 4.89, P = 0.001, respectively] (Fig. 5b).