While in vitro studies have shown that Siglec-6 binds to sialyl Tn (sTn), a truncated O-glycan consisting of sialic acid attached to GalNAc α-O-Serine/Threonine3,26,27, the role of sTn in Siglec-6 mediated migration and adhesion of B-CLL cells is not clear. This evidence concerns the gene EEF1A2 and B-cell chronic lymphocytic leukemia.