Indeed, we observed that MEC1-002 WT and B-CLL cells had increased relative levels of DOCK8 at the cell membrane with a concomitant decrease in nuclear DOCK8 levels when compared to MEC1-002 SIGLEC-6 KO cells and normal donor B cells, respectively, implicating Siglec-6 interaction dependent DOCK8 localization in Siglec-6+ cells. This evidence concerns the gene ATR and B-cell chronic lymphocytic leukemia.