DOCK8 and B-cell chronic lymphocytic leukemia: We observed that Siglec-6 + MEC1-002 WT cells and primary B-CLL cells had higher levels of DOCK8 at the cell membrane [2-fold, t(6) = −5.72, P = 0.001; and 3-fold, t(8) = 3.33, P = 0.01, respectively] when compared to SIGLEC-6 KO MEC1-002 cells and normal donor B cells (Fig. 5b).