ANXA5 and B-cell chronic lymphocytic leukemia: After 5 h in culture, significant cytotoxicity as demonstrated by annexin V/PI staining was observed in the case of B-CLL patient cells (4-fold) when compared to Siglec-6− healthy donor B cells (Fig. 8b), as well as in Siglec-6+ hSiglec-6×TCL1 splenic B cells (2.6-fold) when compared to Siglec-6− TCL splenic B cells (Fig. 8c).