DOCK8 has been previously implicated in T cell and dendritic cell migration via activation of Cdc42, and Arp2/3 complex-driven actin polymerization39,42, but no studies have interrogated Siglec-6/DOCK8 axis-dependent Cdc42 activation in B-CLL cells. Here, DOCK8 is linked to B-cell chronic lymphocytic leukemia.