To understand the connection between YME1L-driven NPC cell progression and the activation of the Akt-mTOR cascade, we introduced a S473D constitutively-active mutant of Akt1 (caAkt1) into YME1L-silenced pNPC-1 cells (kdYME1L). The gene discussed is MTOR; the disease is nasopharyngeal carcinoma.