In other patients-derived primary NPC cells, pNPC-2/-3/-4, YME1L silencing by kdYME1L (see Fig. 2) similarly augmented caspase-3 activity (Fig. 3J) and increased TUNEL-incorporated nuclei percentage (Fig. 3K), indicating activation of the caspase-apoptosis cascade. Here, CASP3 is linked to nasopharyngeal carcinoma.