E2F1 and nonpapillary renal cell carcinoma: Based on these findings, CDC37 and AURKB complexes directly phosphorylate MYC, enhance MYC stability and transcriptional activity, promote Rb phosphorylation and E2F1 release, and in turn activate the transcription of AURKB, forming an AURKB/E2F1 positive feedforward loop that promotes ccRCC progression (Fig. 8J).