Western blotting results showed that after CDC37 knockdown in ccRCC cells, cell cycle G1-related proteins CDK4 and Cyclin D1 were decreased, pro-apoptotic protein Bax increased while Bcl-2 decreased, and migration promoting protein MMP2 was down-regulated (Fig. S5G). Here, MMP2 is linked to nonpapillary renal cell carcinoma.