Western blotting results showed that after AURKB knockdown in ccRCC cells, cell cycle G2-related proteins CDK1 and Cyclin B1 were decreased, pro-apoptotic proteins Caspase 7 and cleaved PARP were increased and migration promoting proteins N-cadherin and MMP2 were down-regulated (Fig. 2I). The gene discussed is AURKB; the disease is nonpapillary renal cell carcinoma.