MAPT and early-onset autosomal dominant Alzheimer disease: Pathological accumulation of the microtubule-associated protein tau is closely associated with cognitive decline in Alzheimer’s disease (AD) [1, 2], and with other tauopathies, such as frontotemporal lobar degeneration-tau (FTLD-tau), which can be directly caused by mutations in the tau gene, MAPT [3, 4].