Three phospho-epitopes were examined: AT8 (pSer202/pThr205) – a phosphoepitope associated with tau aggregation as well as tau accumulation at the post-synaptic compartment [16, 19, 47, 48]; Ser262 – one of the earliest and most significantly changed phosphorylation sites in AD that hinders the association of tau with microtubules [49, 50]; and Ser396 – phosphorylation of which promotes tau mislocalization to the post-synaptic compartment [51] (Fig. 2A, B). Here, MAPT is linked to Alzheimer disease.