TYR and metastatic melanoma: Studies have found that 0–45% of adult primary melanomas and 14–62% of metastatic melanomas express NY-ESO-1 (48.3% primary and metastatic melanomas in this study) [17–19], 61–100% of adult melanomas express tyrosinase (86.2% in this study) [19–21], and 15–37% of adult primary melanomas and 25–81% of metastatic melanomas express MAGE-A3 (75.9% primary and metastatic melanomas in this study) [18, 22, 23].