Most historically established AD markers—including rs6656401 and rs679515 (CR1; MIM: 120620), rs6733839 (BIN1; MIM: 601248), rs9331896 and rs11787077 (CLU; MIM: 185430), and rs6605556 (HLA)26,36,37—showed negligible association. This evidence concerns the gene CLU and Alzheimer disease.