Sporadic FTD (sFTD; ∼70% of all affected individuals) has been associated with genetic risk markers at the TMEM106B, DPP6 (MIM: 126141), UNC13A (MIM: 609894) and HLA-DQA2 (MIM: 613503) loci in cohorts with TDP-43 pathology11,13 and HLA-DRs (MIM: 142860) reported in an sFTD cohort encompassing all clinical subtypes.14 This evidence concerns the gene TMEM106B and frontotemporal dementia.