In addition, for the APOE locus, we assessed several markers that were extensively reported as being genome-wide significant in AD (rs4420638, rs439401, and rs7412)37,38: one of these markers showed significant p value levels, though displaying smaller effect size in the current cohort (rs4420638; p = 9.6 × 10−8 with OR = 3.95 in AD and 1.2 in FTD), while the other two did not (rs439401; p = 8.1 × 10−1 and rs7412; p = 1.9 × 10−4). Here, APOE is linked to Alzheimer disease.