APOE and Alzheimer disease: ,55 The link to the APOE locus could lead to different explanations/interpretations: (1) it may reflect a presence of individuals in our cohort with behavioral variant AD that mimics FTD56,57; (2) it may underpin comorbidities at play, given that some individuals with FTD coming to autopsy can show concurrent AD or vascular changes in addition to changes attributed directly to FTD58,59,60; (3) it may represent a genuine association pertaining to a population-specific subset of individuals with FTD.