Additionally, the protein levels of GLUT1, LDHA, HK2 and VEGF in tumor tissues declined with melittin treatment compared with the hypoxia group, and the levels of these proteins were remarkably increased in the hypoxia+melittin+si-LATS2 group compared to that in the hypoxia+melittin group (Fig. 4D). This evidence concerns the gene LDHA and neoplasm.