To investigate whether the effect of iRGD on the AFP blood level can be detected in mice with endogenously formed HCCs and can be discriminated from the background AFP produced by non-tumoral sites, we examined the effect of iRGD on the blood AFP level in conditional double transgenic TGFα/c-myc mice with HCC (Fig. 1d). The gene discussed is MYC; the disease is hepatocellular carcinoma.