TGFA and hepatocellular carcinoma: ,24 To investigate if the iRGD-induced transport of AFP depends on NRP-1 as well, we studied the effect of a neutralizing anti-NRP-1 antibody on iRGD-induced increase of the blood AFP level in the TGFα/c-myc HCC mice that had given a robust blood AFP response to iRGD one week earlier.