Mechanistically, COR distributes to mitochondria in BV‐2 cells induced by LPS+Aβ, increases ECAR levels and lactate production in the glycolytic pathway by targeting HKII while upregulating OCR levels in PDH‐mediated OXPHOS pathway by targeting PDK2, thus inducing microglial M2 polarization and contributing to AD neuronal survival. This evidence concerns the gene PDP1 and Alzheimer disease.