When MG are overactivated, their polarization state (M1‐like or M2‐like phenotype) will significantly impact the surrounding micro‐environment, which plays a crucial role in the progression of AD.[12] Our analysis of the GSE111737 dataset revealed that genes associated with the M1 phenotype, such as CD86, IL‐6, and CXCL10, exhibited high expression levels in the hippocampus of APP/PS1 mice compared to those in the WT group. Here, APP is linked to Alzheimer disease.