A previous study revealed that NSD2 directly methylated PTEN at K349 and enhanced the DNA damage repair ability in colorectal cancer.[52] NSD2 was found to methylate Aurora kinase A (AURKA) at K14 and K117 and mediate cell proliferation via the p53 signal pathway.[53] Another study also revealed that NSD2 methylated STAT3, which promoted the activation of the STAT3 pathway and enhanced the ability of tumor angiogenesis.[54] In this study, we performed mass spectrometry (MS) analysis and found no evidence that NSD2 directly methylated p65 (data not shown). Here, NSD2 is linked to colorectal cancer.