NSD2 is an important histone methyltransferase,[15] and its oncogenic role in many cancer types has been gradually revealed in recent years.[15, 16, 17] In this study, we demonstrate that NSD2 overexpression restrains pancreatic tumorigenesis, while NSD2 loss facilitates it, by using genetically engineered mouse models (GEMMs) (Figures 1 and 2). This evidence concerns the gene PRDM9 and cancer.