Recent work reported that NSD2‐mediated H3K36me2 promoted EMT, tumor differentiation and metastasis in PDAC using cell lines and orthotopic implantation models.[35] However, our results demonstrated that NSD2 was a tumor suppressor during pancreatic tumorigenesis, using GEMMs models, which develop de novo tumors in a natural immune‐proficient microenvironment, closely mimicking the histopathological and molecular features of human PDAC. Here, NSD2 is linked to neoplasm.