To further analyze the effects of NSD2 loss, we depleted Nsd2 with CRISPR/Cas9 (Nsd2‐KO) in KPC1199, a murine pancreatic cancer cell line derived from KPC mice (PdxCre; LSL‐KrasG12D; LSL‐TP53R172H) and human PDAC cell line ASPC1. This evidence concerns the gene NSD2 and pancreatic neoplasm.