Finally, patients with neutralizing autoantibodies against DNASE1L3 that also bind with high affinity to dsDNA were recently identified in about 30% of patients with SLE (20), and these patients were found to present with more aggressive disease, characterized by higher SELENA-SLEDAI scores at presentation and activated interferon-stimulated gene and neutrophil activation gene cluster signatures (8). Here, DNASE1L3 is linked to systemic lupus erythematosus.