DDX41 and systemic lupus erythematosus: In a dose-response analysis, at concentrations of 0.1, 1.0, or 10 μg/mL, we were able to show, using qPCR, that the human isoform of LBme, called 1833, was able to efficiently degrade cf-gDNA, MP-gDNA, cf-mtDNA, and MP-mtDNA in both samples from HCs and patients with SLE (Figure 9, A–D, respectively, Ct results from one of the HCs and one of the patients with SLE with a known titer of anti-dsDNA Abs).