DNASE1L3 and systemic lupus erythematosus: Soon thereafter, a second population of patients with a pathogenic variant of DNASE1L3 that reduced plasma enzyme concentration by about 80% — R206C (rs35677470) — was found in thousands of patients with lupus, rheumatoid arthritis, and scleroderma, an association that places individuals with this variant at risk for autoimmune disease (13–19).