In summary, the combined anatomic, histologic, and biomarker data suggested that pristane exacerbation of the lupus phenotype in DKO mice led to NETosis, acute respiratory compromise due to alveolar hemorrhage, renal damage, and death, the sequela of which could be prevented by LBme, our enzyme biologic with dual DNASE1 and DNASE1L3 activity. This evidence concerns the gene DNASE1L3 and systemic lupus erythematosus.