DNASE1L3 and systemic lupus erythematosus: We crossed Dnase1L3–/– mice with Dnase1–/– mice to generate Dnase1–/–Dnase1L3–/– double-knockout (DKO) mice on a C57BL/6 background to develop a genetic lupus murine model lacking both DNASE1 and DNASE1L3.