We quantified the formation of pathogenic anti-dsDNA Abs, ANAs, and anti-histone Abs in mice lacking DNASE1L3 and DNASE1, whose autoimmune disease recapitulates human lupus (24–26), and found that pathogenic autoantibodies could be suppressed by weekly doses of LBme as long as dosing was maintained (up to a year) and that death could be prevented following acceleration of the disease phenotype with pristane. This evidence concerns the gene DDX41 and autoimmune disease.