High levels of KMT2A may play a critical part in promoting PAC proliferation through transcriptional upregulation of the proto‐oncogene CCND2, which is mediated by the transcription factors (TFs) signal transducer and activator of transcription 3 (STAT3) and GATA binding protein 3 (GATA3). The gene discussed is CCND2; the disease is gonorrhea.