Changes in the expression of interleukin (IL)-10 family cytokines (IL26, IL-28A, IL28B, and IL29) and their receptor subunits (IL20RB, IL22RA2, and IL28RA), along with other genes related to melanocyte function such as MDM1, IFNA1, IFNB1, IFNG, and ICAM1, have been observed in the skin and peripheral blood mononuclear cells of patients with vitiligo. The gene discussed is IL22RA2; the disease is vitiligo.